The Expression and Correlation of DNA ... - Cancer Research Center

[Abstract]

Objective: In our study, we detect Fragile histidine triad gene ?FHIT? and human DNA mismatch repair genes ?hMMR? hMSH2 in invasive cervical cancer?cervical intraepithelial neoplasia ?CIN? and normal cervixs. To identify the expression of FHIT and hMSH2 in cervical cancer and their possible relationship in the process of cervical cancer?s occurrence and development, aiming to try to provide a new angle of view in its measure.Method: In our study, we selected 35 patients who had invasive cervical cancer?10 patients who had cervical intraepithelial neoplasia ?CIN? and we also included 30 patients who had undergone hysterectomy for begnign uterine pathology, with histologically normal cervix, as a control group. For each patient, we use immunohistochemical analysis to detect the expression of FHIT and hMSH2 genes,furthermore, we analysized the clinical datas to indentify the correlation between the two genes and clinicalcopathological feature.Result:1. Expression of hMSH2: The hMSH2 protein expression was mainly found in nuclear. The positive rate in carcinoma, CIN and normal cervix were 60.0 % ?21/35??70.0% ?7/10? and 30.0% ?9/30?, respectively, the difference was significant ???0.05?. The abnormal expression of hMSH2 had something to do with histological grade ???0.05?, but has no significant difference among other clinicalcopathological features ???0.05?.2. Expression of FHIT?The expression of FHIT protein was in cytoplasmic. The FHIT expression in normal tissue showed to be normal or even positive, no cases occurred descending or short, abnormal one reached 0.0% ?0/30?; in the carcinoma ??and CIN specimens, 22 cases and 4 cases showed the expression descending or short, abnormal one reached 62.9%?22/35? and 40%?4/10?, respectively, difference was significant ???0.05?; The descending and short expression of FHIT had something to do with histological grade ???0.05?. There was no significant difference among other clinicalcopathological features, such as smoking, age, FIGO stage and so on ???0.05?.3. In the carcinoma specimens, there is no significant correlations between the two genes (r_s=-0.097,??0.05).Conclusion:1. The normal expression of human DNA mismatch repair gene ?hMMR? plays a key role in maintaining the genetic stability. The positive rate of hMSH2 protein in CIN?carcinoma,and normal cervix were decreasing by turns, suggesting that the expression of hMSH2 is associated with carcinogenesis of cervical cancer, and its high expression may be a potential marker of CIN and cervical cancer.2. The ascending or descending of FH1T expression plays an important role, which might influence the prognosis of cervical carcinoma.3. The expression of FHIT protein was not associated with the expression of hMSH2 protein significantly (r_s??0.097,??0.05).

Title: The Expression and Correlation of DNA Mismatch Repair Gene hMSH2 and Fragile Histidine Triad FHIT in Cervical Carcinoma

Category: Ovarian Cancer

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Source: http://www.rescancer.com/ovarian-cancer/27289.html

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Inboxhawk ? Different Types Of Vehicle Leasing Solutions

It is absolutely true fact hat these days vehicle leasing is becoming a very popular solution to lending to buying a business vehicle, but it can be a very beneficial solution for individuals as well. Every time you desire to buy a car or even simply rent some auto for a short period of time, vehicle leasing options could be the relevant answer.

It includes renting an automobile, similar to the facilities of leasing a house or an office. When opting for car lease, the finance company gets the automobile of your choice. They then give you a possibility you to use that automobile for the period of the lease in return for a payment that is to be covered per month.

If the automobile is used only for business needs, the repayments charged are completely tax deductible when automobile leasing. It included such issues as renting a depreciation which is your tax deduction.
Benefits
Some of the advantages of vehicle leasing are:
1. Rates can be a tax deduction for vehicles hired for business
2. Car leasing enables you to change your automobile every several years
3. Interest and monthly fees are fixed, so rates are known beforehand
4. Payments are generally considerably lower than a vehicle loan
5. The automobile is used as security against the car lease, so you may expect that the interest rates are normally much lower than automobile loans
6. They provide clients with pretty flexible terms from 2 to 5 years
7. You may get both brand new or used vehicles.

Types of car lease options available
1. operating vehicle leases,
2. finance vehicle leases
3. novated vehicle leases.
It is worth mentioning that the basic difference between finance and operating car lease facilities is at the end of the vehicle leasing term. In the case you opt for an operating lease, the lease lender retains ownership of the automobile leased, whereas in the event of finance leasing, the customer is required to pay out the balloon or residual fees and the client is to assume his ownership. Some issues at the end of a finance vehicle lease are as the following ones: pay out the balloon payment and have the car, trade in the automobile, or refinance the residual payment with some other automobile lease or loan.

It is necessary to admit that a fully maintained automobile lease is a finance leasing option that includes running rates of the car such as different services, tyres fuel, and so on and so forth. This type of automobile leasing is great if you need to have some fixed costs every month.

Novated vehicle leasing works rather differently to finance and operating solutions. In the event you are an employee wanting leasing a car, you are recommended to consider novated vehicle leasing if you desire to salary package an automobile.

Both comments and pings are currently closed.

Source: http://inboxhawk.com/2012/02/02/different-types-of-vehicle-leasing-solutions/

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Dangerous Minds | Things That Cannot Screen For Breast Cancer

Dangerous Minds is a compendium of oddities, pop culture treasures, high weirdness, punk rock and politics drawn from the outer reaches of pop culture. Our editorial policy, such that it is, reflects the interests, whimsies and peculiarities of the individual writers. And sometimes it doesn't. Very often the idea is just "Here's what so and so said, take a look and see what you think."

I'll repeat that: We're not necessarily endorsing everything you'll find here, we're merely saying "Here it is." We think human beings are very strange and often totally hilarious. We enjoy weird and inexplicable things very much. We believe things have to change and change swiftly. It's got to be about the common good or it's no good at all. We like to get suggestions of fun/serious things from our good-looking, high IQ readers. We are your favorite distraction.

Source: http://www.dangerousminds.net/comments/things_that_cannot_screen_for_breast_cancer

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The economics of natural capital

ACB Executive Director Rodrigo Fuentes and Ambassador Stephen Lillie at the dialogue.

The dialogue, spearheaded by the ASEAN Centre for Biodiversity (ACB) was supported by the UK Foreign and Commonwealth Office (FCO).

The event promoted ?The Economics of Ecosystems and Biodiversity? (TEEB) that provides an assessment of the economic impacts associated with losing natural capital and discussed the issues of Payments for Ecosystem Services (PES).

The TEEB ?study finds that under a ?business as usual? scenario, an average year?s natural capital loss would lead to a loss of ecosystem services worth around US$ 2 trillion to $4.5 trillion over a 50-year period. It also describes in economic terms the deep links between eliminating poverty and conserving biodiversity and ecosystems. The TEEB study covers reports for businesses and consumers, national policy makers, and local administrators. You can find more information on the TEEB website.

ACB Executive Director Rodrigo Fuentes said further attention is needed to concentrate efforts at the highest policy and decision-making level and address capacities at technical level to ensure a more effective approach in disseminating TEEB and sustainable financing mechanisms such as PES schemes.

British Ambassador Stephen Lillie delivered the keynote address which highlighted the following:

?One of the key drivers of biodiversity loss in the region is climate change. South East Asia is one of the world?s most vulnerable regions to climate change - reflecting its long coastlines, high concentration of population and economic activity in coastal areas, and heavy reliance on agriculture, natural resources, and forestry.

?The recent UN climate change conference in Durban, South Africa recognised the urgent need to raise the international community?s collective level of ambition to reduce greenhouse gas emissions to keep the average global rise below two degrees Celsius. It was an important step forward, strongly supported by the UK. ?We now need urgently to build on this.

"In 2000 the South East Asia region accounted for about 12% of global emissions, but with rapid economic growth, emissions could increase fourfold by 2030, which would make the region a leading global emitter.? So South East Asian nations will benefit from efforts to tackle climate change, but they also need to be part of the solution.

"Improved management of our ecosystems and biodiversity can make an important contribution to that solution. Conserved or restored forest habitats for example can remove carbon dioxide from the atmosphere, thus helping to address climate change by storing carbon. Conserving intact ecosystems, such as mangroves can help reduce the disastrous impacts of climate change such as flooding and storm surges. By contrast, the loss of forest cover around the world contributes about 20 percent to annual global greenhouse gas emissions.?

John Pearson, Head of the Southeast Asia Climate Change Network based at the British High Commission in Singapore, added, ?Biodiversity has a very high economic value. It provides significant services to society at large. But these benefits are often not recognized, or not given an economic value. A better understanding of this issue can generate support to change policies, and mobilize financial resources to address biodiversity loss and ecosystems degradation. There is ?therefore a compelling need to bring together experts and policy makers involved in economics, science, finance and policy development to identify and implement practical actions to address unsustainable consumption of natural resources.?

During the event, Pearson also presented the impact of a global temperature rise of 40C degree map in South East Asia produced by the Met Office Hadley Centre.

Further information

Click here to download Ambassador Lillie's keynote address.

Source: http://ukinthephilippines.fco.gov.uk/en/news/?view=PressR&id=724126282

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International Business ? Davos Style :

The Intel Hub
James Hall
February 1, 2012

The first lesson of international business is that the monopolies that drive the commercial trading system only hold loyalty to the god of capital.

Making money means retaining a profit on trading transactions of business companies. The notion of MAKING MONEY means something very different to the financial empires that speculate on currencies, commodities, bonds and equities.

When the two worlds come together to celebrate the common interest of their pirate culture, the Davos port of call, is a necessary winter holiday.

No doubt, the world?s financial outlook is still bleak. The needed measures and will to repudiate the ill gained debt bubble, that has much of the world facing insolvency, is a taboo alternative.

The proverbial can that cannot be kicked far enough down the road of postponement keeps the party going for a little while longer. The life style of the super wealthy accustomed to flying into the Alpine village on Gulfstream V?s, hardly relate to the plight of people eating cat food. No surprise, this is the reality that escapes normal reporting.

However, what happens when the EU collapses and nation-states return to their own national currencies? The cardinal rule of the financial buccaneers is to keep the serving of the interest on the debt instruments that they hold as assets, paid by their captive debtors.

When the Fox Business Channel sends a Warren Buffet ?groupie? like Liz Claman to cover this year?s World Economic Forum in Davos, you know you will get soft interviews and approving reporting.

The same can be said of the coverage by most of the financial media. Watching questions at a press conference usually provided a strong sucking sound coming from the journalists in a desperate hope to gain favor among the titans of financial business.

It is refreshing to read in The Economic Times an account about Britain?s Prime Minister David Cameron. His slamming of the eurozone as uncompetitive and branding a planned transaction tax ?madness?, strays from the strategic objectives of the financial elites.

The financial speculation leveraged by the City of London brought the UK to the brink of collapse. Nevertheless, as a lone voice that squelches a retooled ?Tobin Tax?, Cameron deserves credit.

He may just be serving his own domestic political interest, but any opposition to refloating the debt with another round of additional taxes, is a positive. Even if he falls far short with true systemic solutions, the road to global taxation needs derailing.

Cameron scornfully dismissed French-led plan:

?Even to be considering this at a time when we are struggling to get our economies growing is quite simply madness,? he declared.

?Of course it?s right that the financial sector should pay their share. In the UK we are doing exactly that through our bank levies and stamp duty on shares. And these are options which other countries can adopt.?

The legally protected financial bandits are dedicated to the extraction of even higher taxes in order to rollover maturing obligations. As the EU economy falters and shatters, who will bail out the bankrupt economies?

The answer may not exist. John Quelch, the dean of the Shanghai-based China Europe International Business School offers the following assessment in Forbes,

?Last year at Davos, there was wishful thinking about China. Surely China would stumble on its relentless path to economic superpower status, and give the West some breathing space to reboot and revitalize?

This year at Davos, there is also wishful thinking about China, but of a different kind. How can China save the world economy? Surely the Chinese can consume more? And can?t the Chinese government do even more than it already has to prop up the Euro and invest in more Euro denominated assets??

When people mature in their economic understanding, the harsh reality hits them. The criminal elites who designed this perverted global monetary system actually benefit with a total collapse of the nation states.

A total implosion of world markets will not bring down the crooks that already own most of the choice global assets.

Davos is not about advancing productive international business. It is about plotting the next global crisis that drives the plutocrats to demand control that is even more draconian and punitive.

Trade often brings mutual benefits when the marketplace operates with balance and equilibrium. However, when cartels dominate commerce and transnational corporatists force monopolistic restraints upon competing enterprises, the net result dampens alternative markets.

The way to view the business practices of the authoritarian model of the privileged Davos cabal is to see their relationships and overlapping confederations as a filtering system that expels any opposition to their long-term plans for both economic and political domination.

The analogy that describes this difference is seen in the protective environments that the Davos connections operate as compared to the meager existence of the average consumer.

The vast multitude is preoccupied with economic survival. This sharp contrast with the self-appointed shapers of the world financial system, know of no such constraint.

Businesses that actually produce a product or useful service never bridge the gap between practical consumable innovations and the monetary manipulators that feed off the dynamic and industrious efforts of legitimate commercial enterprises. The money interests that dominate gatherings like Davos bring little to the advancement of actual commerce. Wealth creation is different from the accumulation or theft of riches.

The insurmountable resolution of the world debt bubble is evident to everyone. Yet the banksters care little for solutions, especially since their efforts are the true cause of the coming disaster.

The Chinese controlled model will not rescue the globalist trading system. What the Davos elites have in mind is to convert independent economies into subservient appendages of a top down dependent debtor society.

Lowering the standard of living for Western economies is an unpleasant fact. The masters of manipulation desire this outcome.

Until society recognizes that the debt created financial system is the root cause of the next planned panic, none of us will be safe from the crony state/capitalist juggernaut.

James Hall writes for BATR

The Intel Hub News Brief Podcast Series - Listen and Download Now!

Source: http://theintelhub.com/2012/02/01/international-business-davos-style/

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Hershey to invest $10 million in Ivory Coast (AP)

ABIDJAN, Ivory Coast ? The Hershey Company says it will invest $10 million in Ivory Coast to reduce child labor and improve the cocoa supply in the West African nation.

Spokesman Andy McCormick says the measure will bring higher productivity for farmers and will increase supply to meet the demand of a growing middle class in countries like China and India.

Ivory Coast produces 35 percent of the world's cocoa. Combined with coffee, the cocoa sector accounts for 15 percent of GDP. Cocoa production hit a record 1.48 million tons in 2010 despite a political crisis.

UNICEF estimates 600,000 children work on cocoa farms in Ivory Coast and that 35,000 are victims of trafficking.

McCormick says that Hershey is already trying to address child labor issues, "but we all recognize that more needs to be done."

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/ap/20120201/ap_on_bi_ge/af_ivory_coast_cocoa

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Fujitsu slashes profit target by 42 percent, blames Thai floods

NEC revealed its financial woes to the world yesterday and now Fujitsu is doing the same. The Japanese computer giant originally expected to make ¥60 billion ($790 million) in the fiscal year ending March 31st, but its latest estimate suggests ¥35 billion ($460 million) may be closer to the mark. Whereas NEC admitted there'd been a fall in demand for its products, Fujitsu has so far put the blame squarely on the recent flooding in Thailand, which hit PC sales by disrupting supplies of HDDs.

Fujitsu slashes profit target by 42 percent, blames Thai floods originally appeared on Engadget on Tue, 31 Jan 2012 06:14:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/bT_C0Virh4w/

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